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A meta-analysis of the initial and replication studies showed a significant association of the homozygous T allele with a 1.5-fold higher risk of developing statin intolerance ( p = 7 10 5 ) (Siddiqui et al., 2017)

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Ghrelin receptor (GHS-R1a) couples to Gq proteins, activating phospholipase C to generate IP and DAG

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Injection site reactions are the most common issue, presenting as redness, mild swelling, or a small knot at the injection site